61076

DL-4-Hydroxy-2-ketoglutaric acid lithium salt

analytical standard

• Sinónimos: 4-Hydroxy-2-oxoglutaric acid lithium salt, DL-KHG Li
• Fórmula empírica (notación de Hill): C₅H₆O₆ · xLi⁺
• Número de CAS: 1187-99-1
• Peso molecular: 162.10 (free acid basis)
• Beilstein: 1780096
• Código UNSPSC: 41116107

Propiedades

• grado: analytical standard
• Ensayo: ≥97.0% (HPLC)
• caducidad: limited shelf life, expiry date on the label
• aplicaciones: clinical testing
• Formato: neat
• temp. de almacenamiento: −20°C
• InChI: 1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)
• Clave InChI: WXSKVKPSMAHCSG-UHFFFAOYSA-N

Descripción

Descripción general

DL-4-Hydroxy-2-ketoglutaric acid lithium salt (HOG) is a precursor substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA1), a unique enzyme in the hydroxyproline catabolism pathway. It is reported that the primary hyperoxaluria type 3, which is a recently discovered form of the autosomal recessive disease, results from the mutations in the gene coding for HOGA1.

Aplicación

DL-4-Hydroxy-2-ketoglutaric acid lithium salt may be used as an analytical reference standard for the determination of the analyte in animal biological samples using ion chromatography coupled to negative electrospray mass spectrometry (IC/ES-MS). This can be used to determine the primary hyperoxalurias PH Type 3 (PH3), caused by the mutations in the mitochondrial enzyme, 4-hydroxy-2-oxoglutarate aldolase (HOGA).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable