55697

5-Hydroxyindole-3-acetic acid

analytical standard

• Sinónimos: 5-HIAA
• Fórmula empírica (notación de Hill): C₁₀H₉NO₃
• Número de CAS: 54-16-0
• Peso molecular: 191.18
• Beilstein: 168797
• Número MDL: MFCD00005639
• Código UNSPSC: 41116107
• NACRES: NA.24

Propiedades

• grado: analytical standard
• Análisis: ≥98% (HPLC); ≥98% (T)
• caducidad: limited shelf life, expiry date on the label
• mp: 161-164 °C (dec.) (lit.)
• aplicaciones: clinical testing
• formato: neat
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(=O)Cc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
• Clave InChI: DUUGKQCEGZLZNO-UHFFFAOYSA-N

Descripción

Aplicación

• 5-HIAA assay development: Recent advancements include the use of 5-Hydroxyindole-3-acetic acid (5-HIAA) in assay kits aimed at measuring serotonin metabolites accurately, crucial for diagnosing and monitoring treatment outcomes in disorders like carcinoid syndrome. This assay is essential in neurochemistry for evaluating neurotransmitter pathways and their dysregulation (Zhou et al., 2021).


• Neurotransmitter metabolism studies: 5-HIAA is extensively used in research to understand serotonin′s metabolic pathways, offering insights into its role in neurological disorders such as depression and anxiety. This research supports the development of targeted therapies by mapping neurotransmitter fluctuations and interactions (Wang et al., 2024).


• Neurochemical analysis in Parkinson′s disease: Utilizing 5-HIAA, researchers have developed models to explore neurotransmitter dysfunction in Parkinson′s disease, aiding in the understanding of its pathophysiology and contributing to better therapeutic approaches (Couvillion et al., 2023).


• Serotonin degradation studies: 5-HIAA is critical in studying serotonin degradation. This research uses 5-HIAA to quantify serotonin levels and its metabolic effects on the central nervous system (Zhu et al., 2023).


• Development of fluorescent biosensors: Research includes the use of 5-HIAA in the development of novel fluorescent biosensors for detecting serotonin and its metabolites, which are vital for real-time monitoring of these neurochemicals in various biological settings (Zheng et al., 2022).

Acciones bioquímicas o fisiológicas

Major serotonin metabolite.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable