21186

Calcium ionophore III

Selectophore^™, function tested

• Sinónimos: Antibiotic A 23187, Calimycin
• Fórmula empírica (notación de Hill): C₂₉H₃₇N₃O₆
• Número de CAS: 52665-69-7
• Peso molecular: 523.62
• Beilstein: 1096801
• Número CE: 258-084-1
• Número MDL: MFCD00151202
• Código UNSPSC: 26111700
• ID de la sustancia en PubChem: 329752113
• NACRES: NB.61

Propiedades

• grado: for ion-selective electrodes
• Nivel de calidad: 200
• Línea del producto: Selectophore^™
• formulario: solid
• calidad: function tested
• espectro de actividad antibiótica: Gram-positive bacteria; fungi
• Modo de acción: cell membrane | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• Clave InChI: HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Descripción

Descripción general

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

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Aplicación

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Otras notas

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

Información legal

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves