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Merck

16033

Sigma-Aldrich

1,2-Propanediol

meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

Sinónimos:

1,2-PDO, Propylene glycol

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About This Item

Fórmula lineal:
CH3CH(OH)CH2OH
Número de CAS:
Peso molecular:
76.09
Beilstein:
1340498
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
NACRES:
NA.21

densidad de vapor

2.62 (vs air)

Nivel de calidad

presión de vapor

0.08 mmHg ( 20 °C)

Ensayo

≥99.5%

Formulario

liquid

temp. de autoignición

779 °F

calidad

meets analytical specification of Ph. Eur., BP, USP

caducidad

24 mo.

lim. expl.

12.5 %

impurezas

acidic reac. impurities, complies
organic volatile impurities, complies (GC)
oxidizing substances, complies
reducing matter, complies
residual solvents, complies
≤0.0005% heavy metals (as Pb)
≤0.002% free alkali (as NaOH)
≤0.003% free acid (as CH3COOH)
≤0.2% water (Karl Fischer)

residuo de ign.

≤0.005% (as SO4)

índice de refracción

n20/D 1.431-1.433
n20/D 1.432 (lit.)

bp

187 °C (lit.)

mp

−60 °C (lit.)

densidad

1.036 g/mL at 25 °C (lit.)

trazas de anión

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

idoneidad

complies for appearance of solution

grupo funcional

hydroxyl

cadena SMILES

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

Clave InChI

DNIAPMSPPWPWGF-UHFFFAOYSA-N

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Descripción general

1,2-Propanediol is an 1,2-alkanediol. It can be obtained from glycerol, via hydrogenolysis in the presence of Ru/C and Amberlyst ion-exchange resins.
1,2-Propanediol is an important petrochemical that can be prepared by the hydrogenolysis of glycerol. It is mainly used as a cryoprotectant for biological samples and also as an additive in food, cosmetic and pharmaceutical industries.

Aplicación

1,2-Propanediol may be employed as a cryoprotective agent for the preservation (by cooling to sub-zero temperatures) of human embryos and and oocytes (human and mouse).

Envase

bottled under inert gas

Otras notas

The article number 16033-4X5L will be discontinued. Please order the single bottle 16033-5L which is physically identical with the same exact specifications.
The article number 16033-6X1L will be discontinued. Please order the single bottle 16033-1L which is physically identical with the same exact specifications.
The article number 16303-4X2.5L-R will be discontinued. Please order the single bottle 16303-2.5L-R which is physically identical with the same exact specifications.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

219.2 °F - closed cup

Punto de inflamabilidad (°C)

104 °C - closed cup

Equipo de protección personal

Eyeshields, Gloves


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Aqueous phase hydrogenolysis of glycerol to 1, 2-propanediol without external hydrogen addition.
Roy D, et al.
Catalysis Today, 156(1), 31-37 (2010)
D A Gook et al.
Human reproduction (Oxford, England), 8(7), 1101-1109 (1993-07-01)
Human and mouse oocytes were cryopreserved by a slow freeze, rapid thaw method, using propanediol (PROH) as the cryoprotectant. A simulated cryopreservation was also included in the study to detect the level of damage attributable to the PROH alone. Comparison
Glycerol hydrogenolysis to 1, 2-propanediol catalyzed by a heat-resistant ion-exchange resin combined with Ru/C.
Miyazawa T, et al.
Applied Catalysis A: General, 329, 30-35 (2007)
B Lassalle et al.
Fertility and sterility, 44(5), 645-651 (1985-11-01)
Eighty-five human embryos fertilized in vitro were frozen and thawed with 1,2 propanediol as a cryoprotective agent. The effects of viability of in vitro culture duration, stage, and morphologic appearance of embryos were examined after thawing. Survival was higher for
Yusha Imtiaz et al.
Nanomaterials (Basel, Switzerland), 10(8) (2020-08-23)
Polysaccharides have been shown to have immunomodulatory properties. Modulation of the immune system plays a crucial role in physiological processes as well as in the treatment and/or prevention of autoimmune and infectious diseases. Cellulose nanocrystals (CNCs) are derived from cellulose

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