PC41
Anti-Cathepsin B (Ab-3) Rabbit pAb
liquid, Calbiochem®
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.43
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
purified antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
liquid
contiene
≤0.1% sodium azide as preservative
reactividad de especies
human
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
do not freeze
isotipo
IgG
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
modificación del objetivo postraduccional
unmodified
Descripción general
Anti-Cathepsin B (Ab-3), rabbit polyclonal, recognizes the ~43 kDa latent and ~31 kDa active forms of cathepsin B in breast carcinoma. It is validated for Western blotting and for paraffin sections.
Purified rabbit polyclonal antibody. Recognizes the ~43 kDa latent and the ~31 kDa active forms of cathepsin B.
Recognizes the ~43 kDa latent and the ~31 kDa active forms of cathepsin B in breast carcinoma tissues.
Inmunógeno
Human
purified human liver cathepsin B
Aplicación
Immunoblotting (1 µg/ml)
Paraffin Sections (2.5 µg/ml, trypsin pre-treatment required)
Paraffin Sections (2.5 µg/ml, trypsin pre-treatment required)
Envase
Please refer to vial label for lot-specific concentration.
Advertencia
Toxicity: Standard Handling (A)
Forma física
In 0.05 M sodium phosphate buffer, 0.2% gelatin.
Nota de análisis
Positive Control
SK-HEP-1 concentrated conditioned medium or breast carcinoma tissue
SK-HEP-1 concentrated conditioned medium or breast carcinoma tissue
Otras notas
Antibody should be titrated for optimal results in individual systems.
Barrett, A.J. and Kirschke, H. 1981. Methods Enzymol.80, 535.
Chan, S.J., et al. Proc. Natl. Acad. Sci. USA83, 7721.
Barrett, A.J. 1987. Trends Biochem. Sci.12, 193.
Sloane, B.F. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 137.
Chan, S.J., et al. Proc. Natl. Acad. Sci. USA83, 7721.
Barrett, A.J. 1987. Trends Biochem. Sci.12, 193.
Sloane, B.F. 1990. in Seminars in Cancer Biology, ed. M. M. Gottesman. Vol. 1(2), 137.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
B F Sloane
Seminars in cancer biology, 1(2), 137-152 (1990-04-01)
The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and
S J Chan et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(20), 7721-7725 (1986-10-01)
Cathepsin B is a lysosomal thiol proteinase that may have additional extralysosomal functions. To further our investigations on the structure, mode of biosynthesis, and intracellular sorting of this enzyme, we have determined the complete coding sequences for human and mouse
Paola Pellegrini et al.
Autophagy, 10(4), 562-571 (2014-02-05)
Acidic pH is an important feature of tumor microenvironment and a major determinant of tumor progression. We reported that cancer cells upregulate autophagy as a survival mechanism to acidic stress. Inhibition of autophagy by administration of chloroquine (CQ) in combination
Xian Zhang et al.
iScience, 19, 607-622 (2019-08-26)
Transforming growth factor beta (TGF-β) signaling contributes to tissue fibrosis. Here we demonstrate that TGF-β enhances CatS and CatK expression but reduces CatB and CatL expression in mouse kidney tubular epithelial cells (TECs). CatS- and CatK deficiency reduces TEC nuclear
Cathepsin B, Cathepsin H, and cathepsin L.
A J Barrett et al.
Methods in enzymology, 80 Pt C, 535-561 (1981-01-01)
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