MABS1284-B

Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate

clone LPA4, from mouse, biotin conjugate

• Sinónimos: Apo(a), Lp(a)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: biotin conjugate
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: LPA4, monoclonal
• reactividad de especies: human, nonhuman primates
• técnicas: ELISA: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotipo: IgG1κ
• Nº de acceso UniProt: P08519
• Condiciones de envío: ambient
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... APOA1(335)

Descripción

Descripción general

Apolipoprotein(a) (UniProt P08519; also known as Apo(a), Lp(a)) is encoded by the LPA gene (Gene ID 4018) in human. Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It is synthesized with a signal peptide (aa 1-19) that is subsequently cleaved off. Lipoprotein (a)/Lp(a) is composed of Apo(a) covalently bound to apolipoprotein B-100/ApoB via a single disulfide bond on kringle (K)IV type 9 (KIV9) to a site near ApoB low density lipoprotein (LDL) receptor-binding site. Structurally, Apo (a) contains ten subtypes of KIV sequences, with the KIV2 subtype present in multiple identical repeats, followed by a KV sequence and an inactive protease domain. Elevated levels of Lp(a) are considered as a risk factor in the development of cardiovascular diseases and peripheral arterial disease. Lp(a) is a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and circulating levels of oxidized LDL are strongly associated with angiographically documented coronary artery disease. Apo(a) is known to be proteolytically cleaved. Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis.

Especificidad

Clone LPA4 detects Apolipoprotein(a) in human and non-human primates.

Inmunógeno

Human Lipoprotein a (Lp(a)).

Aplicación

Anti-Apolipoprotein(a), clone LPA4, Biotin Conjugate, Cat. No. MABS1284-B, is a mouse monoclonal antibody that detects Apolipoprotein (a)/Apo(a)/Lp(a) in human and non-human primates and has been tested for use in ELISA, Immunoprecipitation, and Western Blotting.

ELISA Analysis: A representative lot detected Apolipoprotein(a) in ELISA applications (Pedersen, T.X., et. al. (2010). J Lipid Res. 51(10):2967-75; Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

ELISA Analysis: 0.1 µg/mL from a representative lot detected Apolipoprotein(a) in Patient Lp(a) Plasma sample (Courtesy of Dr. Sotirios Tsimikas, M.D., University of California at San Diego, USA).

Immunoprecipitation Analysis: A representative lot detected Apolipoprotein(a) in Immunoprecipitation applications (Tsimikas, S., et. al. (2004). Circulation. 109(25):3164-70).

Western Blotting Analysis: A representative lot detected Apolipoprotein(a) in Western Blotting applications (Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

Research Category
Signaling

Calidad

N/A

Descripción de destino

501.32 kDa calculated for Apolipoprotein A

Forma física

Protein G purified

Purified mouse monoclonal antibody IgG1 in PBS with 1.5% BSA and 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): does not flash
• Punto de inflamabilidad (°C): does not flash