MABN352

Anti-delta-type Opioid Receptor, clone 4E6.2 Antibody

clone 4E6.2, from mouse

• Sinónimos: Delta-type opioid receptor, D-OR-1, DOR-1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: 4E6.2, monoclonal
• reactividad de especies: human, mouse
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• isotipo: IgG2bκ
• Nº de acceso NCBI: NP_000902
• Nº de acceso UniProt: P41143
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... OPRD1(4985)

Descripción

Descripción general

Delta-type Opioid Receptor (D-OR-1), also known as DOR-1, and encoded by the gene name OPRD1/ OPRD, is a G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Binding of Delta-type Opioid Receptor with ligands causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Delta-type Opioid Receptor signaling has been shown to lead to the inhibition of adenylate cyclase activity. Recent studies have also demonstrated that Delta-type Opioid Receptor inhibits the neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Delta-type Opioid Receptor also may play a role in the perception of pain and in opiate-mediated analgesia. Additionally, it may play a role in developing analgesic tolerance to morphine, and it may form homooligomers. Delta-type Opioid Receptor interacts with GPRASP1. Delta-type Opioid Receptor is detected in oocytes (at protein level), and in brain cortex, hypothalamus, hippocampus and olfactory bulb.

Inmunógeno

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human delta-type Opioid Receptor.

Aplicación

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected delta-type Opioid Receptor in human cerebral cortex, human uterus, and human thalamus tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-delta-type Opioid Receptor antibody is validated for use in WB, IH(P) for the detection of delta-type Opioid Receptor.

Calidad

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected delta-type Opioid Receptor in 10 µg of mouse brain tissue lysate.

Descripción de destino

~65 kDa observed. The calculated molecular weight of this protein is 40 kDa, but can be observed at ~65 kDa due to high glycosylation.

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable