MABN1595
Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1
clone 9B11.1, from mouse
Sinónimos:
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, 5-HT2A, Serotonin receptor 2A
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
9B11.1, monoclonal
reactividad de especies
mouse, rat, human
técnicas
immunohistochemistry: suitable
western blot: suitable
isotipo
IgG2aκ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... HTR2A(3356)
Descripción general
5-hydroxytryptamine receptor 2A (UniProt P28223; also known as 5-HT-2, 5-HT-2A, 5-HT2A, Serotonin receptor 2A) is encoded by the HTR2A (also known as HTR2) gene (Gene ID 3356) in human. Hydroxytryptamine (5-HT) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT2A receptor, which couples to Gq/11 to increase intracellular calcium, is widely expressed at central and peripheral sites of 5-HT action and contributes to many of the physiological effects of 5-HT. The hallucinogenic activity of LSD is mediated in part by its action as a partial to full agonist of 5-HT2A receptor, and the activity of atypical antipsychotics such as clozapine appears to be mediated in part by antagonism against 5-HT2A receptor. Human 5-HT2A receptor contains four extracellular domains (a.a. 1-75, 133-148, 216-233, 347-362), seven transmembrane segments (a.a. 76-99, 111-132, 149-171, 192-215, 234-254, 325-346, 363-384), and four cytoplasmic domains (a.a. 100-110, 172-191, 255-324, 385-471).
Especificidad
Expected to react with both spliced isoforms of human Serotonin receptor 2A reported by UniProt (P28223).
Inmunógeno
Epitope: Third cytoplasmic domain.
GST-tagged recombinant fragment corresponding to the third cytoplasmic domain of human Serotonin receptor 2A/HTR2A.
Aplicación
Immunohistochemistry Analysis: An 1:50 dilution from a representative lot detected 2A/HTR2A in human cerebral cortex, mouse cerebral cortex, and rat testis tissue sections.
Research Category
Neuroscience
Neuroscience
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
This Anti-Serotonin receptor 2A/HTR2A Antibody, clone 9B11.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of SHTR2A.
Calidad
Evaluated by Western Blotting in human cerebral cortex tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected 2A/HTR2A in 10 µg of human cerebral cortex tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected 2A/HTR2A in 10 µg of human cerebral cortex tissue lysate.
Descripción de destino
~52 kDa observed. 52.60 kDa (isoform 1) and 43.94 kDa (isoform 2) calculated.
Forma física
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt.
Otras notas
Concentration: Please refer to lot specific datasheet.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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