MABF390

Anti-CD152 (CTLA-4) Antibody (mouse), PE, clone UC10-4F10-11

clone UC10-4F10-11, 0.2 mg/mL, from hamster(Armenian)

• Sinónimos: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: hamster (Armenian)
• Nivel de calidad: 100
• conjugado: PE
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: UC10-4F10-11, monoclonal
• reactividad de especies: mouse
• concentración: 0.2 mg/mL
• técnicas: flow cytometry: suitable
• isotipo: IgG
• Nº de acceso UniProt: P09793
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: mouse ... Ctla4(12477)

Descripción

Descripción general

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Inmunógeno

Immunogen information for this antibody is proprietary information.

Aplicación

Research Category
Inflammation & Immunology

This armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), PE & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).

Calidad

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 µg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

Forma física

Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

Size Exclusion Chromatography

Almacenamiento y estabilidad

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable