MABC663

Anti-TICAM1 Antibody, clone 3D5.1

clone 3D5.1, from mouse

• Sinónimos: TICAM1, TIR domain-containing adapter molecule 1, TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, My
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 3D5.1, monoclonal
• reactividad de especies: human
• técnicas: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• isotipo: IgG2aκ
• Nº de acceso NCBI: NP_891549
• Nº de acceso UniProt: Q8IUC6
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TICAM1(148022)

Descripción

Descripción general

TIR domain-containing adapter molecule 1 (UniProt Q8IUC6), also known as MyD88-3, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kB-activating protein 502H, TICAM-1, TIR domain containing adaptor inducing interferon-b, TIR domain-containing adapter protein inducing IFN-b, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon b) is encoded by the TICAM1 gene in human. TCAM-1/TRIF/MyD88-3 is as an adaptor molecule that mediates Toll-like receptor 3 (TLR3)-dependent NF-kB activation and cytokine expression. Upon recognition of double-stranded RNA, TLR3 recruits TRIF, which in turn associates with TNF receptor-associated factor 3 (TRAF3) to activate two Ik-B kinase (IKK)-related kinases, TANK-binding kinase 1 (TBK1) and IKKi. These two kinases phosphorylate interferon regulatory factor 3/7 (IRF3/7), resulting in the induction of type I interferons (IFNs) and expression of IFN-inducible genes. TICAM-1 can also mediate NF-kB activation through receptor-interacting protein 1 (RIP1) and TRAF6. Human enterovirus 68 (EV68) is reported to disable TLR3 pathway signaling by cleaving TRIF in infected cells.

Inmunógeno

GST-tagged recombinant protein corresponding to human TICAM1.

Aplicación

Anti-TICAM1 Antibody, clone 3D5.1 is an antibody against TICAM1 for use in Western Blotting, Immunohistochemistry, Immunocytochemistry.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TICAM1 in human liver tissue.
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected TICAM1 in HeLa and A431 cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Calidad

Evaluated by Western Blotting in Raji cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TICAM1 in 10 µg of Raji cell lysate.

Descripción de destino

~76 kDa observed

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable