MABC42

Anti-Pleiotrophin Antibody, clone 3B10

clone 3B10, from mouse

• Sinónimos: pleiotrophin, neurite growth-promoting factor 1, Heparin-binding brain mitogen, heparin binding growth factor 8, Heparin-binding growth-associated molecule, heparin affin regulatory protein, Heparin-binding neurite outgrowth-promoting factor 1, pleiotrop
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: 3B10, monoclonal
• reactividad de especies: human
• técnicas: immunohistochemistry: suitable; western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: XP_416358
• Nº de acceso UniProt: P32760
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PTN(5764)

Descripción

Descripción general

Pleiotrophin (PTN) also called Neurite Growth-promoting Factor 1 (NEGF1) or HARP (Heparin affin regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN plays an important role in development processess and promotion of neurite extension. During embryonic development, pleiotrophin is expressed in the central and peripheral nervous system, lung, kidney, gut and bone. Pleiotrophin is also expressed by several tumor cells and is thought to be involved in tumor angiogenesis. PTN initiates an angiogenic switch in different cancer models and acts as an angiogenic factor. PTN does this through an interaction with endothelial cells to initiate proliferation, migration, and tube formation.

Inmunógeno

Recombinant protein corresponding to chicken Pleiotrophin.

Aplicación

Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected Pleiotrophin in papillary squamous cell carcinoma tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Developmental Neuroscience

This Anti-Pleiotrophin Antibody, clone 3B10 is validated for use in IH, WB for the detection of Pleiotrophin.

Calidad

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Pleiotrophin in 10 µg of human placenta tissue lysate.

Descripción de destino

~20 kDa observed

Ligadura / enlace

Replaces: MABD179

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing PBS without 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Nota de análisis

Control
Human placenta tissue lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable