MAB3729
Anti-c-met Antibody, clone 4AT44
clone 4AT44, Chemicon®, from mouse
Sinónimos:
Hepatocyte Growth Factor Receptor, HGFR
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clon:
4AT44, monoclonal
application:
WB
reactividad de especies:
mouse, human
técnicas:
western blot: suitable
citations:
2
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
4AT44, monoclonal
reactividad de especies
mouse, human
fabricante / nombre comercial
Chemicon®
técnicas
western blot: suitable
isotipo
IgG1
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... MET(4233)
mouse ... Met(17295)
Especificidad
Reacts with c-met/HGFR (Hepatocyte growth factor receptor). The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for c-met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal c-met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.
Inmunógeno
Purified recombinant catalytic domain of human Met
Aplicación
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
This Anti-c-met Antibody, clone 4AT44 is validated for use in WB for the detection of c-met.
Western Blot: 1:100-1:500.
ELISA (direct): 1:1,000
Optimal working dilutions must be determined by the end user.
ELISA (direct): 1:1,000
Optimal working dilutions must be determined by the end user.
Ligadura / enlace
Replaces: 04-1051
Forma física
Format: Purified
Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.
Almacenamiento y estabilidad
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Knudsen, BS; Zhao, P; Resau, J; Cottingham, S; Gherardi, E; Xu, E; Berghuis, B; Daugherty et al.
Applied Immunohistochemistry & Molecular Morphology null
Antibody validation by quantitative analysis of protein expression using expression of Met in breast cancer as a model.
Pozner-Moulis, S; Cregger, M; Camp, RL; Rimm, DL
Laboratory Investigation; a Journal of Technical Methods and Pathology null
Wafaa M Rashed et al.
Journal of cancer research and clinical oncology, 147(1), 167-175 (2020-09-28)
Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play
Simone Buraschi et al.
The Journal of biological chemistry, 285(53), 42075-42085 (2010-10-27)
A theme emerging during the past few years is that members of the small leucine-rich proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine kinases (RTKs), mostly by a physical down-regulation of the receptors, thereby depriving tumor
Xiaobin Wang et al.
Journal of cellular and molecular medicine, 25(21), 10164-10174 (2021-10-16)
Mantle cell lymphoma (MCL) is a haematologic malignancy. The proteasome inhibitor (PI) bortezomib has been approved to treat MCL, but resistance has emerged through mechanisms that remain unclear. This study aimed to explore the mechanism of PI resistance in MCL
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