MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

clone 689, from mouse

• Sinónimos: EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 689, monoclonal
• reactividad de especies: mouse
• reactividad de especies (predicha por homología): chicken (based on 100% sequence homology), human (based on 100% sequence homology)
• técnicas: ELISA: suitable; immunohistochemistry: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_115823
• Nº de acceso UniProt: Q75N90
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... EFEMP1(2202)

Descripción

Descripción general

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

Especificidad

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

Inmunógeno

Recombinant protein corresponding to human Fibrillin 3.

Aplicación

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

Calidad

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

Descripción de destino

~ 350 kDa calculated

Forma física

Format: Purified

Nota de análisis

Control
Mouse skin tissue

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable