GF168

BMP-6 Protein, Human Recombinant

The Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.

• Sinónimos: Bone Morphogenetic Protein 6, BMP6, VRR-1, VG-1-related protein
• Código UNSPSC: 12352202
• eCl@ss: 32160405

Propiedades

• Nivel de calidad: 100
• Análisis: >95% (SDS-PAGE and HPLC)
• impurezas: <0.1 μg/mg protein endotoxin (<1EU/μg)
• Nº de acceso UniProt: P22004
• Condiciones de envío: dry ice

Descripción

Descripción general

Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

Product Source: HEK293 Cells

Especificidad

Cross Reactivty
None

Aplicación

Research Category
Stem Cell Research

Research Sub Category
Growth Factors & Receptors

Calidad

Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.

Forma física

Product is filtered through a 0.2 micron filter before lyophilization.

Almacenamiento y estabilidad

Store at -20°C for up to 6 months from date of receipt.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable