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Merck
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EZHPI

Millipore

Human Proinsulin ELISA Kit

measures and quantifies Proinsulin levels in 20 μL serum or plasma

Sinónimos:

Human Proinsulin Detection, Proinsulin ELISA

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About This Item

Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.32

Nombre del producto

Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.

Nivel de calidad

200

reactividad de especies

human

envase

kit of 1 × 96 wells

Parámetros

20 μL sample volume (4hr assay)

assay range

accuracy: 88-103%
linearity: 84-120%
sensitivity: 0.5 pM
standard curve range: 2-200 pM

técnicas

ELISA: suitable

entrada

sample type serum
sample type plasma (K2 EDTA)

Nº de acceso NCBI

NM_000207.2

Nº de acceso UniProt

P01308

aplicaciones

research use

método de detección

colorimetric (450nm)

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

Descripción general

Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.

Aplicación

Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.

Otras notas

Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature

Cláusula de descargo de responsabilidad

For research use only. Not for use in diagnostic procedures.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palabra de señalización

Warning

Frases de peligro

H290,H317

Clasificaciones de peligro

Met. Corr. 1 - Skin Sens. 1

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Michael A Weiss
The Journal of biological chemistry, 284(29), 19159-19163 (2009-04-28)
Insulin plays a central role in the regulation of vertebrate metabolism. The hormone, the post-translational product of a single-chain precursor, is a globular protein containing two chains, A (21 residues) and B (30 residues). Recent advances in human genetics have
Carolina Isiegas et al.
Investigative ophthalmology & visual science, 57(8), 3610-3618 (2016-07-09)
The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated
Flora de Pablo et al.
Frontiers in molecular neuroscience, 11, 426-426 (2018-12-12)
Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied

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