CBL479
Anti-Integrin β3 Antibody, clone PM6/13
clone PM6/13, Chemicon®, from mouse
Sinónimos:
CD61
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
clon
PM6/13, monoclonal
reactividad de especies
human
fabricante / nombre comercial
Chemicon®
técnicas
flow cytometry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotipo
IgG1
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... ITGB3(3690)
Especificidad
The antibody is specific for the 110 kDa platelet glycoprotein GP IIIa and inhibits platelet aggregation and activation induced by thrombin and collagen. The platelet glycoprotein is the integrin beta3 chain of the vitronectin receptor and GPIIb/IIIa. The antigen is present on platelets and megakaryocytes.
Antigen distribution:
Platelets >98%
Megakaryocytes >98%
Granulocytes 0%
Monocytes 0%
LGL cells 0%
B cells 0%
T cells 0%
Peripheral blood lymphocytes 0%
FUSION PARTNER: SP2/0 myeloma cell line
Antigen distribution:
Platelets >98%
Megakaryocytes >98%
Granulocytes 0%
Monocytes 0%
LGL cells 0%
B cells 0%
T cells 0%
Peripheral blood lymphocytes 0%
FUSION PARTNER: SP2/0 myeloma cell line
Inmunógeno
Human platelet plasma membrane
Aplicación
FACS: As a marker for megakaryoblastic/cytic leukaemias and idiopathic thrombocythemia
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
This Anti-Integrin β3 Antibody, clone PM6/13 is validated for use in FC, IP, WB, IH, IH(P) for the detection of Integrin β3.
Ligadura / enlace
Replaces: MAB1381
Forma física
Format: Purified
The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Almacenamiento y estabilidad
For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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D Boettiger et al.
Molecular biology of the cell, 12(5), 1227-1237 (2001-05-22)
Integrin receptors serve as mechanical links between the cell and its structural environment. Using alpha(v)beta3 integrin expressed in K562 cells as a model system, the process by which the mechanical connection between alpha(v)beta3 and vitronectin develops was analyzed by measuring
Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth.
Do?ate, F; Parry, GC; Shaked, Y; Hensley, H; Guan, X; Beck, I; Tel-Tsur, Z; Plunkett et al.
Clinical cancer research : an official journal of the American Association for Cancer Research null
Vineet Gupta et al.
Journal of immunology (Baltimore, Md. : 1950), 180(3), 1713-1718 (2008-01-23)
Formation of the integrin alphabeta heterodimer is essential for cell surface expression and function. At the core of the alphabeta interface is a conserved Arg/Lys "finger" from the beta-subunit that inserts into a cup-like "cage" formed of two layers of
D Ma et al.
Thrombosis and haemostasis, 105(6), 1032-1045 (2011-04-09)
A novel family of RGD-containing molecules (Tablysin-15) has been molecularly characterised from the salivary gland of the haematophagous horsefly Tabanus yao. Tablysin-15 does not share primary sequence homology to any disintegrin discovered so far, and displays an RGD motif in
Hee Doo Lee et al.
European journal of immunology, 44(4), 1156-1169 (2013-12-18)
Integrin trafficking, including internalization, recycling, and lysosomal degradation, is crucial for the regulation of cellular functions. Exosomes, nano-sized extracellular vesicles, are believed to play important roles in intercellular communications. This study demonstrates that exosomes released from human macrophages negatively regulate
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