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Key Documents

CBL1360

Sigma-Aldrich

Anti-CD117 Antibody, clone ACK2

clone ACK2, Chemicon®, from rat

Sinónimos:

c-kit, SCF Receptor

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rat

Nivel de calidad

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

ACK2, monoclonal

reactividad de especies

mouse

fabricante / nombre comercial

Chemicon®

técnicas

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

entrada

sample type hematopoietic stem cell(s)
sample type mesenchymal stem cell(s)

isotipo

IgG2bκ

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... KIT(3815)

Descripción general

This 145 kDa molecule is a member of the tyrosine kinase receptor family and is expressed by a majority of hematopoietic progenitor cells. The interaction of the mouse c-kit receptor and steel factor promotes proliferation and differentiation of hematopoietic progenitor cells. CD117 is also expressed by mast cells, and plays a role in signaling and activation of these cells.

Especificidad

Specifically recognizes mouse CD117, known as c-kit receptor, stem cell factor receptor and steel factor receptor.

Aplicación

Detect CD117 using this Anti-CD117 Antibody, clone ACK2 validated for use in FC, IH, IP, FUNC & WB.
Flow Cytometry: 0.2 μg per 10e6 cells

Immunoprecipitation

Immunohistochemistry (Frozen)

Western blot

Blocking Ligand Binding

Optimal working dilutions must be determined by the end user.
Research Category
Stem Cell Research
Research Sub Category
Hematopoietic Stem Cells

Mesenchymal Stem Cells

Descripción de destino

145 kDa

Ligadura / enlace

Replaces: CBL1360P

Forma física

Format: Purified
Protein A purified
The monoclonal is presented in phosphate buffered saline containing 10mM sodium azide.

Almacenamiento y estabilidad

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.

Nota de análisis

Control
Skin tissue, normal breast epithelium, melanocytes, mast cells and glial cells

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Código de clase de almacenamiento

10 - Combustible liquids


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Cheng-Hai Zhang et al.
Nature communications, 7, 11358-11358 (2016-04-23)
Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we
L Sha et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3840-3849 (2010-06-15)
Gastric and small intestinal circular smooth muscle layers have a transwall resting membrane potential (RMP) gradient that is dependent on release of carbon monoxide (CO) from interstitial cells of Cajal (ICCs). Our aim was to determine whether a RMP gradient
S Vincent et al.
Development (Cambridge, England), 125(22), 4585-4593 (1998-10-21)
The Kit receptor and its ligand KL, which together constitute an essential effector at various stages of embryonic development, are both present during adult gametogenesis. In the testis, KL is expressed in Sertoli cells, and Kit in germ cells, starting
Masutaka Tokuda et al.
Biology of reproduction, 76(1), 130-141 (2006-10-13)
In the mammalian testis, spermatogenesis is initiated from a subset of stem cells belonging to undifferentiated type A spermatogonia. In spite of the biologic significance of undifferentiated type A spermatogonia, little is known about their behavior and properties because of
Emily J Poulin et al.
Stem cell research, 13(3 Pt A), 422-430 (2014-12-03)
Lrig1 is an intestinal stem cell marker important for epithelial homeostasis. However, the position of the Lrig1(+) population in the intestinal crypt has been debated, largely due to discrepant staining patterns using two Lrig1 antibodies. Here, we set out to

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