ABT29

Anti-Tensin-3 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• técnicas: immunocytochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NP_073585
• Nº de acceso UniProt: Q68CZ2
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TNS3(64759)

Descripción

Descripción general

Tensin-3 is a member of the Tensin family of proteins that serve as a connection between the cytoskeleton and extracellular matrix. Because of this link, Tensin’s are commonly thought to regulate signaling for the shape of the cell and motility. Tensin-3 localizes in the cell cytoplasm and has been shown to be significantly decreased in many different human cancer cell lines. Higher expression levels of Tensin-3 were also found to be associated with longer survival. Tensin-3 has also been found to be highly expressed in functioning thyroid follicular adenomas while expression is significantly lower in non-functioning thyroid follicular adenomas, which seems to imply that Tensin-3 has an important role in basic thyroid function.

Inmunógeno

KLH-conjugated linear peptide corresponding to human Tensin-3.

Aplicación

Anti-Tensin-3 Antibody detects level of Tensin-3 & has been published & validated for use in WB & IC.

Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Tensin-3 in A431 cells.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

Cytoskeleton

Calidad

Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Tensin-3 in 10 µg of human kidney tissue lysate.

Descripción de destino

~180 kDa observed.
The calculated molecular weight is 155 kDa, however Tensin-3 has been shown as a ~180 kDa band in western blots (Cui, Y., et al. (2004). Molecular Cancer Research. 2:225–232).
An uncharacterized band appears at ~22 kDa in some lysates.

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Human kidney tissue lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable