ABN470

Anti-EPAC1 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Rap guanine nuclear exchange factor 3, RAPGEF3, cAMPGEF-I, bcm910, cAMP-GEFI, Exchange factor directly activated by cAMP, cAMP-regulated guanine nucleotide exchange factor I, EPAC1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, rat
• técnicas: immunohistochemistry: suitable; western blot: suitable
• Nº de acceso UniProt: O95398
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... RAPGEF3(10411)

Descripción

Descripción general

Exchange protein directly activated by cAMP 1 (EPAC1) is also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I. EPAC1 is a guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases which are activated through cAMP binding. EPAC1 couples cAMP production to the activation of the Ras family GTPase, Rap. Activation of Rap drives several cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. EPAC1 is part of a signaling complex in which it activates the PI3K gamma complex, which is involved in angiogenesis. EPAC1 may also regulate ion channel formation, intracellular Ca++ signaling, ion transporter activity, and exocytosis. EPAC1 is widely expressed, especially in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord.

Inmunógeno

KLH-conjugated linear peptide corresponding to human EPAC1.

Aplicación

Anti-EPAC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected EPAC1 in human kidney, thalamus, and cerebellum tissues.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Calidad

Evaluated by Western Blotting in rat skeletal muscle tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected EPAC1 in 15 µg of rat skeletal muscle tissue lysate.

Descripción de destino

~103 kDa observed. Uncharacterized bands may appear in some lysate(s).

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Rat skeletal muscle tissue lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable