ABN348

Anti-TTBK1 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Tau tubulin kinase 1, brain derived tau kinase, BDTK, TTBK1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, mouse
• técnicas: immunohistochemistry: suitable; western blot: suitable
• Nº de acceso UniProt: Q5TCY1
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TTBK1(84630)

Descripción

Descripción general

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.

Especificidad

This antibody is predicted to not cross-react with TTBK2.

Inmunógeno

KLH-conjugated linear peptide corresponding to human TTBK1.

Aplicación

Immunohistochemistry Analysis: 2.5 µg/mL of this antibody from a representative lot detected. TTBK1 in mouse brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This TTBK1 antibody is validated for use in WB & IHC for the detection of the TTBK1 protein.

Calidad

Evaluated by Western Blot in Jurkat cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected TTBK1 in 15 µg of Jurkat cell lysate.

Descripción de destino

~143 kDa observed

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Jurkat cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable