ABF293

Anti-RNASET2 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Ribonuclease T2, Ribonuclease 6
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• clon: polyclonal
• application: WB
• reactividad de especies: human
• técnicas: western blot: suitable

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• técnicas: western blot: suitable
• Nº de acceso UniProt: O00584
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... RNASET2(8635)

Descripción

Descripción general

Ribonuclease T2, also known as Ribonuclease 6, and encoded by the gene name RNASET2 or RNASE6PL, is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.

Inmunógeno

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human RNASET2.

Aplicación

Anti-RNASET2 Antibody detects level of RNASET2 & has been published & validated for use in RNASET2.

Research Category
Inflammation & Immunology

Research Sub Category
Inflammation & Autoimmune Mechanisms

Calidad

Evaluated by Western Blotting in SW480 cell lysate with and without blocking peptide.

Western Blotting Analysis: 2 μg/mL of this antibody detected RNASET2 in SW480 cell lysate with and without blocking peptide.

Descripción de destino

~40 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 2 isoforms produced by alternative splicing at ~40 kDa, ~14 kDa, and ~29 kDa

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable