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Key Documents

ABC463

Sigma-Aldrich

Anti-Osteoprotegerin/TNFRSF11B Antibody

from rabbit, purified by affinity chromatography

Sinónimos:

Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

purificado por

affinity chromatography

reactividad de especies

human

técnicas

immunohistochemistry: suitable (paraffin)
western blot: suitable

Nº de acceso NCBI

NP_002537

Nº de acceso UniProt

O00300

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... TNFRSF11B(4982)

Descripción general

Osteoprotegerin/TNFRSF11B, also known as Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, or Osteoprotegerin, (OPG), and encoded by the gene TNFRSF11B/OCIF/OPG, is a membrane bound receptor that acts as a decoy receptor for TNFSF11/RANKL and thereby helps to neutralize or regulate its function in osteoclastogenesis. Bone homeostasis is at least partially dependent upon the levels of TNFSF11 and TNFSF11B, and by acting as decoy or "extra" receptor for TNFSF11B the excess factor levels can be modulated. The activation of the receptors inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. OPG also seems to act as a decoy receptor for TNFSF10/TRAIL and help prevent against TRAIL mediated apoptosis, and TRAIL acts as antagonist for osteoclastogenesis, and thus again OPG appears to moderate osteoclast levels in a dynamic fashion. OPG is highly expressed in numerous tissues other than developing and adult bone germinal centers, but its exact role in these other tissues is still being examined.

Especificidad

Immunogen is 92% identical in bovine and in mouse. Immunogen is 84% identical in rat.

Inmunógeno

Epitope: TNFR-Cys 2 domain
KLH-conjugated linear peptide corresponding to the TNFR-Cys 2 domain of human Osteoprotegerin/TNFRSF11B.

Aplicación

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Osteoprotegerin/TNFRSF11B in human kidney tissue.
This Anti-Osteoprotegerin/TNFRSF11B Antibody is validated for use in western blotting & IHC (Paraffin) for the detection of Osteoprotegerin/TNFRSF11B.

Calidad

Evaluated by Western Blotting in MG63 conditioned media.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Osteoprotegerin/TNFRSF11B in 10 µg of MG63 conditioned media.

Descripción de destino

~55 kDa observed. Protein is heavily glycosylated and often observed as a monomer at ~55-60 kDa (Cundy T., et al. (2002) Hum Mol Genet. 11(18):2119-27).

Otras notas

Concentration: Please refer to lot specific datasheet.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tim Cundy et al.
Human molecular genetics, 11(18), 2119-2127 (2002-08-22)
Idiopathic hyperphosphatasia is an autosomal recessive bone disease characterized by deformities of long bones, kyphosis and acetabular protrusion, increasing in severity as affected children pass through adolescence. Biochemical and histological evidence indicate that there is extremely rapid bone turnover, with
Chun-Sheng Bi et al.
Clinical and experimental dental research, 5(4), 377-388 (2020-01-17)
This study aimed to investigate the relationship between inflammation-related T-helper cell polarization and the receptor activator for nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) ratio, which is associated with bone resorption or remodeling of chronic periodontitis patients. Gingival crevicular fluid (GCF) and

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