AB9433-I

Anti-GLP1R Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: GLP-1R, GLP-1 Receptor, GLP1-R, GLP1R,GLP-1-R
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, mouse
• técnicas: immunohistochemistry: suitable (paraffin)
• Nº de acceso NCBI: NP_002053
• Nº de acceso UniProt: P43220
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... GLP1R(2740)

Descripción

Descripción general

Glucagon-Like Peptide 1 Receptor (GLP-1R) is the receptor for glucagon-like peptide 1 and is expressed in the pancreatic beta cells. Ligand binding activates adenyl-cyclase activity which results in increased insulin synthesis and release. GLP-1R is also expressed in the brain where it functions in the control of appetite, memory and learning. GLP-1R also has neuroprotective functions which may be beneficial in diseases such as Huntington′s disease, and drugs that are GLP-1R agonists (acts like natural ligand to activate the receptor) such as Exendin-4 are being examined as potential therapies for the disease as well as diabetes and other memory and metabolic disorders.

Inmunógeno

Epitope: extracellular domain, near N-Terminus

KLH-conjugated linear peptide corresponding to the extracellular domain of Human Glucagon-Like Peptide 1 Receptor.

Aplicación

Research Category
Metabolism

Signaling

Research Sub Category
Lipid Metabolism & Weight Regulation

Lipid Signaling

This Anti-GLP1R Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of GLP1R.

Calidad

Evaluated by Immunohistochemistry (Paraffin) on endocrine cells in human pancreas.

Immunohistochemistry Analysis: 2 ug/ml this antibody showed cytoplasmic staining of subsets of endocrine cells in islets of Langerhans in human pancreas.

Descripción de destino

53 kDa calculated

Ligadura / enlace

Replaces: AB9433

Forma física

Antigen Affinity Purified

Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable