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Key Documents

AB9080

Sigma-Aldrich

Anti-Ryanodine Receptor 2 Antibody

serum, Chemicon®

Sinónimos:

Anti-ARVC2, Anti-ARVD2, Anti-RYR-2, Anti-RyR, Anti-VACRDS, Anti-VTSIP

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

serum

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

mouse, human, rat

fabricante / nombre comercial

Chemicon®

técnicas

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... RYR2(6262)

Especificidad

Ryanodine Receptor 2.

Inmunógeno

Synthetic peptide from the variant TM region of human Ryanodine Receptor 2.

Aplicación

Anti-Ryanodine Receptor 2 Antibody is an antibody against Ryanodine Receptor 2 for use in IC, IH & WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

Signaling Neuroscience
Western blot: 1:1,000 using ECL. The antibody reacts with the 500 kDa Ryanodine Receptor 2 protein. Suggested blocking buffer is 10% normal goat serum (or same host as your secondary antibody), 1% BSA in 0.1M PBS with 0.05% Tween 20. Suggested dilution buffer is 1% normal goat serum (or same host as your secondary antibody), 1% BSA in 0.1M PBS with 0.05% Tween 20. Preferred gel percentage is 4-12% gradient gel.

Immunocytochemistry: 1:1,000

Immunohistochemistry: 1:1,000 overnight at 2-8°C using a fluorescently labeled secondary antibody. Suggested fixative is 4% paraformaldehyde in 0.1M PBS (one hour). Suggested permeablization method is 0.05% Triton X-100 in dilution buffer. Suggested blocking buffer is 10% normal goat serum (or same host as your secondary antibody) and 1% BSA in 0.1M PBS. Suggested dilution buffer is 1% normal goat serum (or same host as your secondary antibody) and 1% BSA in 0.1M PBS.

Optimal working dilutions must be determined by the end user.

Forma física

Rabbit serum. Liquid.

Almacenamiento y estabilidad

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Nota de análisis

Control
Western blot = adult mouse cardiac muscle or brain (adult mouse skeletal muscle will be negative).

IHC = adult mouse cerebellum Purkinje cells (adult mouse cerebellum granular cells will be negative).

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.
Garcia-Perez, C; Hajnoczky, G; Csordas, G
The Journal of Biological Chemistry null
Local Ca2+ releases enable rapid heart rates in developing cardiomyocytes.
Korhonen T, Rapila R, Ronkainen VP, Koivum??ki JT, Tavi P
The Journal of Physiology null
Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.
Dixit, SS; Wang, T; Manzano, EJ; Yoo, S; Lee, J; Chiang, DY; Ryan, N; Respress et al.
Testing null
Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.
Huang, W; Xing, W; Ryskamp, DA; Punzo, C; Krizaj, D
Experimental Eye Research null
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca?+-dysregulation aging phenotype in hippocampal neurons.
Gant, JC; Chen, KC; Norris, CM; Kadish, I; Thibault, O; Blalock, EM; Porter, NM; Landfield, PW
The Journal of Neuroscience null

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