AB2984

Anti-Integrin beta 3 (ITGB3/CD61) Antibody

rabbit polyclonal

• Sinónimos: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), Platelet membrane glycoprotein IIIa, integrin beta-3, platelet glycoprotein IIIa, CD61 antigen
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• Nombre del producto: Anti-Integrin beta-3 Antibody, from rabbit, purified by affinity chromatography
• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human, pig
• reactividad de especies (predicha por homología): rat (based on 100% sequence homology), canine (based on 100% sequence homology), porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology)
• técnicas: immunohistochemistry: suitable (paraffin); immunoprecipitation (IP): suitable; western blot: suitable
• Nº de acceso NCBI: NP_000203
• Nº de acceso UniProt: P05106
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ITGB3(3690)

Descripción

Descripción general

Integrin beta-3 is a member of the Integrin receptor family. The integrin family has been shown to be instrumental in cell adhesion to extracellular matrix proteins and can be found in certain cell to cell adhesions. Integrins are also important in transmembrane connections and intracellular signaling. Integrins are key to understanding many human diseases as they are commonly the receptors. Integrins have been linked to many different parts of cellular operations including; development, immunity, leukocyte traffic, homeostasis and even cancer. Once integrin beta-3 is activated, it binds fibrinogen which causes platelet to platelet interaction effectively cutting off a ruptured endothelial surface.

Especificidad

Other homologies: Mouse (93% sequence homology.)

This antibody recognizes the extracellular domain of integrin beta-3.

Inmunógeno

Epitope: Extracellular Domain

KLH-conjugated linear peptide corresponding to human integrin beta-3 at the extracellular domain.

Aplicación

Anti-Integrin beta-3 Antibody is an antibody against Integrin beta-3 for use in WB, IP, IH(P).

Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected intergin beta-3 in skin membrane tissue.

Immunoprecipitaiton Analysis: 10 µg from a previous lot immunoprecipitated integrin beta-3 from U251 RIPA lysate.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

Calidad

Evaluated by Western Blot in U251 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin beta-3 in 10 µg of U251 cell lysate.

Descripción de destino

~85 kDa observed.
Uncharacterized bands may be observed in some lysates.

Ligadura / enlace

Replaces: 04-1060

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
U251 cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable