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AB15794

Sigma-Aldrich

Anti-Dexras1 Antibody

Chemicon®, from rabbit

Sinónimos:

Activator of G-Protein Signaling 1, AGS1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

purificado por

affinity chromatography

reactividad de especies

mouse

reactividad de especies (predicha por homología)

rat (100% immunogen homology), human (100% immunogen homology)

fabricante / nombre comercial

Chemicon®

técnicas

western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... RASD1(51655)

Descripción general

Dexras1 is a member of the superfamily of RAS-g-proteins and directly binds to Gialpha heterotrimeric G-proteins where it appears to promote guanine nucleotide exchange on Gialpha. Dexras1 is implicated in NMDA receptor signaling through nitric oxide synthase.

Especificidad

Dexras1 (Activator of G-Protein Signaling 1, AGS1). By Western blot the antibody recognizes a band at ~33 kDa on mouse brain extract. The antibody has also been used to detect Dexras1 in brown adipocyte lysate.
Other species have not been tested

Inmunógeno

Synthetic peptide.

Aplicación

Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience
This Anti-Dexras1 Antibody is validated for use in WB for the detection of Dexras1.
Western blot: 1:1,000 on mouse brain extract.
Optimal working dilutions must be determined by the end user.

Forma física

ImmunoAffinity Purified
Liquid in PBS. Contains no preservative

Almacenamiento y estabilidad

6 months at -70°C from date of shipment

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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M J Cismowski et al.
The Journal of biological chemistry, 275(31), 23421-23424 (2000-06-07)
Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activator of G-protein signaling), is a human Ras-related G-protein
T E Graham et al.
Endocrinology, 142(6), 2631-2640 (2001-05-18)
Dexras1 is a novel GTP-binding protein that shares structural similarity with the Ras family of small molecular weight GTPases and is strongly and rapidly induced during treatment with dexamethasone. The function of Dexras1 and its contribution to glucocorticoid-dependent signaling in
M J Cismowski et al.
Nature biotechnology, 17(9), 878-883 (1999-09-03)
We describe genetic screens in Saccharomyces cerevisiae designed to identify mammalian nonreceptor modulators of G-protein signaling pathways. Strains lacking a pheromone-responsive G-protein coupled receptor and expressing a mammalian-yeast Galpha hybrid protein were made conditional for growth upon either pheromone pathway
Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
McGrath, MF; Ogawa, T; de Bold, AJ
American Journal of Physiology. Heart and Circulatory Physiology null
M Fang et al.
Neuron, 28(1), 183-193 (2000-11-22)
Because nitric oxide (NO) is a highly reactive signaling molecule, chemical inactivation by reaction with oxygen, superoxide, and glutathione competes with specific interactions with target proteins. NO signaling may be enhanced by adaptor proteins that couple neuronal NO synthase (nNOS)

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