869006-M

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade

• Sinónimos: Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH
• Número de CAS: 9002-71-5
• Código UNSPSC: 12352202

Propiedades

• origen biológico: human pituitary glands
• Nivel de calidad: 100
• esterilidad: non-sterile
• Análisis: ≥95% (weight)
• formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• técnicas: enzyme immunoassay: suitable
• impurezas: ≤0.1% hPRL (weight); ≤0.2% hGH, hFSH (weight); ≤0.3% hLH (weight)
• solubilidad: 0.05 M PBS: 1 mg/mL
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... TSHB(7252)

Descripción

Descripción general

Research area: Cell Signaling

Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.

Acciones bioquímicas o fisiológicas

Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.

Advertencia

Toxicity: Standard Handling (A)

Definición de unidad

1mg/ml in 0.05M PBS

Nota de preparación

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable