869001-M

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

• Sinónimos: Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH
• Número de CAS: 9002-68-0
• Número MDL: MFCD00131099
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human pituitary glands
• Nivel de calidad: 200
• esterilidad: non-sterile
• Línea del producto: Calbiochem^®
• Análisis: ≥90%
• formulario: lyophilized solid
• actividad específica: ≥2000 IU/mg
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• impurezas: ≤0.1% hCG; ≤0.5% hLH, hTSH
• pI: 4.1
• solubilidad: PBS: soluble
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Acciones bioquímicas o fisiológicas

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Nota de preparación

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Costrici, N., et al. 1995. Endocrinology136, 4705.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable