8.52090

Fmoc-Tyr(PO(NMe₂)₂)-OH

Novabiochem^®

• Sinónimos: Fmoc-Tyr(PO(NMe₂)₂)-OH, N-α-Fmoc-O-(bis-dimethylamino-phosphono)-L-tyrosine
• Fórmula empírica (notación de Hill): C₂₈H₃₂N₃O₆P
• Número de CAS: 172611-23-3
• Peso molecular: 537.54
• Código UNSPSC: 12352209
• NACRES: NA.22

Propiedades

• Nivel de calidad: 200
• Línea del producto: Novabiochem^®
• Ensayo: ≥93.0% (acidimetric); ≥96% (TLC); ≥96.0% (HPLC)
• Formulario: powder
• idoneidad de la reacción: reaction type: Fmoc solid-phase peptide synthesis
• fabricante / nombre comercial: Novabiochem^®
• aplicaciones: peptide synthesis
• grupo funcional: Fmoc
• temp. de almacenamiento: 15-25°C

Descripción

Descripción general

Fmoc-Tyr(PO(NMe₂)₂)-OH is a useful derivative for the synthesis of phosphotyrosine-containing peptides by Fmoc SPPS ^[1]. As the side-chain phosphate group is fully protected, this derivative is compatible with all coupling methods.Regeneration of phosphotyrosine from the phosphodiamidate is effected by acid catalyzed hydrolysis using 90% aq. TFA.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

^[1] H. G. Chao, et al. (1995) J. Org. Chem., 60, 7710.

Ligadura / enlace

Replaces: 04-12-1205

Nota de análisis

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 96.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 93.0 %
Water (K. F.): ≤ 4.5 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Información legal

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable