8.22278

Acetic anhydride

for synthesis

• Sinónimos: Acetic anhydride, Acetyl acetate, Acetyl oxide
• Fórmula lineal: (CH₃CO)₂O
• Número de CAS: 108-24-7
• Peso molecular: 102.09
• Número MDL: MFCD00008705
• Código UNSPSC: 12352106
• Número índice de la CE: 203-564-8
• NACRES: NA.22

Propiedades

• presión de vapor: 4 hPa ( 20 °C)
• Nivel de calidad: 200
• Ensayo: ≥98.0% (GC)
• Formulario: liquid
• temp. de autoignición: 330 °C
• potencia: 630 mg/kg LD₅₀, oral (Rat); 4320 mg/kg LD₅₀, skin (Rabbit)
• lim. expl.: 2.0-10.2 % (v/v)
• pH: 3 (20 °C, 10 g/L in H₂O)
• mp: -73 °C
• temperatura de transición: flash point 49 °C
• densidad: 1.08 g/cm³ at 20 °C
• temp. de almacenamiento: 2-30°C
• InChI: 1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
• Clave InChI: WFDIJRYMOXRFFG-UHFFFAOYSA-N

Descripción

Descripción general

Acetic anhydride is a widely used reagent in organic synthesis. The reagent is effective for acetylating alcohols, amines, and thiols. Additionally, it is used in various named reactions such as the Pummerer reaction, the Perkin reaction, the Polonovski reaction, the N-oxide reaction, and the Thiele reaction. Acetic anhydride is an effective reagent during oxidation of alcohols, dehydration, ether cleavage, enol acetate formation, and gem-diacetate formation.

Aplicación

Acetic anhydride is used:

• In the solvent free acylation of 2-methylfuran to 2-acetyl-5-methylfuran in presence of hydroxide fluorides catalyst.
• As a catalyst in the synthesis of 3-arylideneisobenzofuran-1(3H)-one derivatives from phthalic anhydride and quinoline derivatives.
• In the preparation of hyperbranched poly ethoxy siloxanes by condensation reaction with tetra ethoxy silane in presence of an organotitanium catalyst.

Nota de análisis

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.080 - 1.082
Identity (IR): passes test

Información de seguridad

• Pictogramas: GHS02,GHS05,GHS06
• Palabra de señalización: Danger
• Frases de peligro: H226 - H302 - H314 - H330
• Consejos de prudencia: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 120.2 °F - closed cup
• Punto de inflamabilidad (°C): 49 °C - closed cup