691400

Zebularine

A cell-permeable chemically stable cytidine analog that displays antitumor properties.

• Sinónimos: Zebularine, 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
• Fórmula empírica (notación de Hill): C₉H₁₂N₂O₅
• Número de CAS: 3690-10-6
• Peso molecular: 228.20
• Número MDL: MFCD04973699
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: off-white
• solubilidad: DMSO: 5 mg/mL; methanol: 5 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2
• Clave InChI: RPQZTTQVRYEKCR-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Cytidine deaminase

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Nota de preparación

Slight warming may be required to achieve complete solubilization.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.





From Catalog:

Desc. Field- added "cell-permeable"

Otras notas

Cheng, J.C., et al. 2004. Cancer Cell6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399.
Zhou, L., et al. 2002. J. Mol. Biol.321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536.
Frick, L., et al. 1989. Biochemistry28, 9423.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable