573103

STAT3 Inhibitor VII

The STAT3 Inhibitor VII, also referenced under CAS 1041438-68-9, controls the biological activity of STAT3.

• Sinónimos: STAT3 Inhibitor VII, Ethyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
• Fórmula empírica (notación de Hill): C₁₉H₇F₇N₂O₃
• Número de CAS: 1041438-68-9
• Peso molecular: 444.26
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to light orange
• solubilidad: DMSO: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC₅₀ against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Xu, J., et al. 2008. J. Med. Chem.51, 4115.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable