567734

S1P₁ Receptor Agonist III

The S1P1 Receptor Agonist III controls the biological activity of S1P1 Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Sinónimos: S1P₁ Receptor Agonist III, 4-Methoxy-N-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)nicotinamide, Sphingosine-1-Phosphate₁ Receptor Agonist III
• Fórmula empírica (notación de Hill): C₂₁H₁₆F₃N₃O₃
• Número de CAS: 1324003-64-6
• Peso molecular: 415.37
• Número MDL: MFCD27991276
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(NC(C1=CN=CC=C1OC)=O)NC(C=C2)=CC(C(F)(F)F)=C2C3=CC=CC=C3

Descripción

Descripción general

An orally bioavailable polar head group lacking carbamoylnicotinamide compound that acts as a potent and reversible agonist of hS1P₁ receptor (EC₅₀ = 35 nM with 96% efficacy) with substantial to excellent selectivity over hS1P₅ (EC₅₀ = 4.3 µM with 58% efficacy) and hS1P_2-4 (EC₅₀ >25 µM). Minimally affects the activities of hERG (IC₅₀ >10 µM) and cytochrome p450 isozymes (IC₅₀ >30 µM for 3A4 and 2D6), and exhibits desirable microsomal stability and aqueous solubility, Shown to efficiently reduce the circulating lymphocyte levels in rats (1 mg/kg, p.o.).

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Pennington, L.D., et al. 2011. Bioorg. Med. Chem. Lett.22, 527.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable