565950

Sialyl Lewis x, Sodium Salt

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.

• Sinónimos: Sialyl Lewis x, Sodium Salt, SLe ^x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc, SLe^x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc
• Fórmula empírica (notación de Hill): C₃₁H₅₁N₂NaO₂₃
• Número de CAS: 98603-84-0
• Peso molecular: 842.73
• Número MDL: MFCD00270073
• Código UNSPSC: 12352201
• NACRES: NA.79

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (TLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: water: 2 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• InChI: 1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
• Clave InChI: LAQPKDLYOBZWBT-NYLDSJSYSA-N

Descripción

Descripción general

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia, reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable