553031

RAGE Antagonist Peptide, RAP

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

• Sinónimos: RAGE Antagonist Peptide, RAP, ELKVLMEKEL
• Fórmula empírica (notación de Hill): C₅₇H₁₀₁N₁₃O₁₇S
• Peso molecular: 1272.55
• Código UNSPSC: 12352111
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Análisis: ≥95% (HPLC)
• formulario: powder
• potencia: 2 μM IC₅₀
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: water: 5 mg/mL
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

Acciones bioquímicas o fisiológicas

Primary Target
RAGE

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Secuencia

Ac-ELKVLMEKEL-NH2

Forma física

Supplied as a trifluoroacetate salt.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable