539209

Protein Arginine N-Methyltransferase Inhibitor, AMI-1

The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: Protein Arginine N-Methyltransferase Inhibitor, AMI-1, PRMT Inhibitor I
• Fórmula empírica (notación de Hill): C₂₁H₁₂N₂Na₄O₉S₂
• Peso molecular: 592.42
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• solubilidad: water: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC₅₀ = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC₅₀ = 5 µM).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Protein arginine N-methyltransferases (PRMTs)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable