5.32177

Tdp1 Inhibitor, CD00509

• Sinónimos: Tdp1 Inhibitor, CD00509, Tyrosyl-DNA phosphodiesterase 1 Inhibitor
• Fórmula empírica (notación de Hill): C₉H₆N₂O₃S
• Número de CAS: 27430-18-8
• Peso molecular: 222.22
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥97% (HPLC)
• Nivel de calidad: 100
• formulario: powder
• potencia: 710 nM IC₅₀
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: soluble
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell permeable alkylidene barbiturate analog that acts as a potent and specific inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1; IC₅₀ = 710 nM) and increases the number of g-H2AX foci in MCF-7 cells. Shown to sensitize MCF-7 cells to camptothecin (CPT), increase DNA breaks, and reduce cell proliferation. However, it does not affect the viability of normal mammary epithelial cells up to 10 µM levels. Synergistically reduces cell proliferation and induces apoptosis in MCF-7 cells when combined with Rucaparib, a PARP-1 inhibitor.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Tdp1

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Dean, R.A., et al. 2014. J. Biolmol. Screen.19, 1372.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable