528105

Picrotoxin, Anamirta cocculin

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

• Sinónimos: Picrotoxin, Anamirta cocculin
• Fórmula empírica (notación de Hill): C₁₅H₁₈O₇ · C₁₅H₁₆O₆
• Número de CAS: 124-87-8
• Peso molecular: 602.58
• Número MDL: MFCD00074824
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (mixture of Picrotoxin and picrotin, HPLC)
• formulario: crystals; powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white to light yellow
• solubilidad: aqueous base: 3 mg/mL; ethanol: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1
• Clave InChI: VJKUPQSHOVKBCO-ZTYBEOBUSA-N

Descripción

Descripción general

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^- channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
GABA receptors

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

Advertencia

Toxicity: Highly Toxic (H)

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
Yoon, K.W., et al. 1993. J. Physiol.464, 423.
Akaike, N., et al. 1985. Experientia41, 70.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable