513100

DL-threo-PDMP, Hydrochloride

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.

• Sinónimos: DL-threo-PDMP, Hydrochloride, 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol, HCl
• Fórmula empírica (notación de Hill): C₂₃H₃₈N₂O₃ · xHCl
• Número de CAS: 80938-69-8
• Peso molecular: 390.56 (free base basis)
• Número MDL: MFCD00236490
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: DMSO: soluble; ethanol: soluble; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
• Clave InChI: HVJHJOYQTSEKPK-BLDCTAJRSA-N

Descripción

Descripción general

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and is a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured 3T3 cells.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
glycolipid synthesis in cultured NIH/3T3 cells

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Irritant (B)

Otras notas

Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable