5.08438

Lamellipodial Growth Promoter, C8N6 BPA Polyamine

• Sinónimos: Lamellipodial Growth Promoter, C8N6 BPA Polyamine, Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
• Fórmula empírica (notación de Hill): C₂₀H₄₈N₆ · 6HCl
• Número de CAS: 870087-09-5
• Peso molecular: 591.40
• Número MDL: MFCD00048297
• Código UNSPSC: 12352116
• NACRES: NA.77

Propiedades

• Ensayo: ≥95% (NMR)
• Nivel de calidad: 100
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: off-white
• solubilidad: water: 100 mg/mL; DMSO: 50 mg/mL
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Nedeva, I., et al. 2013. Nat. Commun.4, 2165.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable