487960

Nociceptin

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1).

• Sinónimos: Nociceptin, Orphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
• Fórmula empírica (notación de Hill): C₇₉H₁₂₉N₂₇O₂₂
• Número de CAS: 170713-75-4
• Peso molecular: 1809.04
• Número MDL: MFCD00677528
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
• Clave InChI: PULGYDLMFSFVBL-SMFNREODSA-N

Descripción

Descripción general

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity at the µ, δ, or κ opioid receptors; however, nanomolar concentrations of Nociceptin inhibit, forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH

Otras notas

Madeddu, P., et al. 1999. Hypertension 33, 914.
Sandin, J., et al. 1999. NeuroReport 10, 71.
Meunier, J., et al. 1995. Nature 377, 532.
Reinscheid, R.K., et al. 1995. Science 270, 792.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable