475838

Mifepristone

≥99% (titration), solid, progesterone and glucocorticoid receptor antagonist, Calbiochem^®

• Sinónimos: Mifepristone, (11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486
• Fórmula empírica (notación de Hill): C₂₉H₃₅NO₂
• Número de CAS: 84371-65-3
• Peso molecular: 429.59
• Número MDL: MFCD00867226
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Mifepristone, A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.
• Nivel de calidad: 100
• Ensayo: ≥99% (titration)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• impurezas: ≤0.1% Steroid substances
• color: yellow
• solubilidad: ethanol: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
• Clave InChI: VKHAHZOOUSRJNA-GCNJZUOMSA-N

Descripción

Descripción general

A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

A cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Progesterone and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitución

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

McCullers, D.L., et al. 2002. Neuroscience109, 219.
Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci.955, 159.
Gao, F., et al. 2001. Acta Pharmacol. Sin.22, 524.
Hyder, S.M., et al. 2001. Int. J. Cancer92, 469.
Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
Sridhar, S., et al. 2001. Cancer Res.61, 7179.
Behl, C., et al. 1997. Eur. J. Neurosci.9, 912.
Greb, R.R., et al. 1997. Hum. Reprod.12, 1280.
Gruol, D.J., et al. 1994. Cancer Res.54, 3088.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H360
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable