474780

MG-115

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

• Sinónimos: MG-115, Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII
• Fórmula empírica (notación de Hill): C₂₅H₃₉N₃O₅
• Número de CAS: 133407-86-0
• Peso molecular: 461.59
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥90% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
• Clave InChI: QEJRGURBLQWEOU-FKBYEOEOSA-N

Descripción

Descripción general

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
20S proteasome

Product does not compete with ATP.

Reversible: yes

Target K_i: 21 nM and 35 nM for 20S and 26S proteasome, respectively

Advertencia

Toxicity: Standard Handling (A)

Secuencia

Z-Leu-Leu-Nva-CHO

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable