422706

KN-62

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.

• Sinónimos: KN-62, 1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II, 1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
• Fórmula empírica (notación de Hill): C₃₈H₃₅N₅O₆S₂
• Número de CAS: 127191-97-3
• Peso molecular: 721.84
• Número MDL: MFCD00083180
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated; protect from light
• color: off-white
• solubilidad: methanol: 5 mg/mL; DMSO: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3
• Clave InChI: RJVLFQBBRSMWHX-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, reversible, and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (K_i = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
cam kinase 2

Product does not compete with ATP.

Reversible: yes

Target K_i: 900 nM for rat brain CaM kinase II

Advertencia

Toxicity: Standard Handling (A)

Nota de preparación

Further dilute with aqueous buffer just prior to use.

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Otras notas

Minami, H., et al. 1994. Biochem. Biophys. Res. Commun.199, 241.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable