420355

Isoprenaline hydrochloride

≥99% (TLC), solid, β-adrenoceptor agonist, Calbiochem

• Sinónimos: Isoproterenol, Hydrochloride
• Fórmula empírica (notación de Hill): C₁₁H₁₇NO₃ · xHCl
• Número de CAS: 51-30-9
• Peso molecular: 211.26 (free base basis)
• Número MDL: MFCD00012603
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Isoproterenol, Hydrochloride, Phenethylamine derivative.
• Nivel de calidad: 100
• Ensayo: ≥99% (TLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to off-white; white
• solubilidad: ethanol: soluble; water: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
• Clave InChI: IROWCYIEJAOFOW-UHFFFAOYSA-N

Descripción

Descripción general

Phenethylamine derivative. Selective β-adrenergic agonist that increases cytosolic cAMP. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^- diffusion and potential difference in rabbit trachea cells through nitric oxide generation.

Phenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^– diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
β-adrenergic agonist

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Irritant (B)

Reconstitución

Unstable in solution; reconstitute just prior to use.

Otras notas

Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem.275, 25342.
Carmena, M.J., et al. 1997. Prostate 33, 46.
Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
Kishimoto, I., et al. 1994. J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994. Mol. Cell Biochem.141, 27.
Yashiro, K., et al. 1994. J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993. J. Neurochem.60, 260.
von Zastrow, M., et al. 1993. J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable