385880

Hsp25 Kinase Inhibitor

The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Hsp25 Kinase Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor, MAPKAP Kinase-2 Inhibitor, MK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor
• Fórmula empírica (notación de Hill): C₆₁H₁₁₃N₂₁O₁₆
• Peso molecular: 1396.68
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: DMSO: soluble; water: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (K_i = 8.1 µM) and non-competitive with respect to ATP (K_i = 134 µM).

A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (K_i = 8.1 µM) and non-competitive with respect to ATP (K_i = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
(Hsp25) kinase

Product does not compete with ATP.

Reversible: no

Target K_i: 8.1 µM against (Hsp25) kinase

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH

Forma física

Supplied as a trifluoroacetate salt.

Reconstitución

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Otras notas

Katsoulidis, E., et al. 2005. Cancer Res.65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable