324732

ErbB2 Inhibitor II

The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: ErbB2 Inhibitor II, 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
• Fórmula empírica (notación de Hill): C₁₅H₁₀N₄O
• Número de CAS: 928207-02-7
• Peso molecular: 262.27
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 50 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC₅₀ = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC₅₀ of 30.9 µM.

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem.15, 1533.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3