309866

Diltiazem, Hydrochloride

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist.

• Sinónimos: Diltiazem, Hydrochloride, L-Type Calcium Channel Blocker II
• Fórmula empírica (notación de Hill): C₂₂H₂₆N₂O₄S · xHCl
• Número de CAS: 33286-22-5
• Peso molecular: 414.52 (free base basis)
• Número MDL: MFCD00069252
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 50 mg/mL; chloroform: soluble; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• Clave InChI: HDRXZJPWHTXQRI-BHDTVMLSSA-N

Descripción

Descripción general

Synthetic (+)-cis isomer that acts as an L-type Ca²⁺ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
L-type Ca2+ channel

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Otras notas

van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable