220551

Chloramphenicol

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

• Sinónimos: Chloramphenicol
• Fórmula empírica (notación de Hill): C₁₁H₁₂Cl₂N₂O₅
• Número de CAS: 56-75-7
• Peso molecular: 323.13
• Número MDL: MFCD00078159
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥97% (by Assay)
• formulario: crystalline powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: gray to off-white
• solubilidad: water: 2.5 mg/mL; methanol: 35 mg/mL; ethanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
• Clave InChI: WIIZWVCIJKGZOK-UHFFFAOYSA-N

Descripción

Descripción general

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

Acciones bioquímicas o fisiológicas

Potency: ≥970 µg/mg

Primary Target
trasnslation of RNA

Otras notas

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS08,GHS05
• Palabra de señalización: Danger
• Frases de peligro: H318,H351,H361fd
• Consejos de prudencia: P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Carc. 2 - Eye Dam. 1 - Repr. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3