208922-M

CaMKII Inhibitor, CK59

The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: CaMKII Inhibitor, CK59, 2-(2-Hydroxyethylamino)-6-aminohexylcarbamic acid tert-butyl ester-9-isopropylpurine, CK59
• Fórmula empírica (notación de Hill): C₂₁H₃₇N₇O₃
• Número de CAS: 140651-18-9
• Peso molecular: 435.56
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: semisolid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 10 mg/mL
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
• Clave InChI: AYZRKFOEZQBUEA-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC₅₀<10 µM) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 µM) and GLUT4 membrane translocation (IC₅₀ = 100 µM) in 3T3-L1 adipocytes.

A cell-permeable Olomoucine analog that acts as a CaMKII inhibitor (IC₅₀<10 M) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 M) and GLUT4 membrane translocation (IC₅₀ = 100 M) in 3T3-L1 adipocytes.

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution aliquot, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Konstantopoulos, N., et al. 2007. Endocrinology, 148, 374.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable